Julie Sutcliffe Receives SNMMI Mars Shot Fund Award

Julie Sutcliffe, professor of biomedical engineering and internal medicine at University of California, Davis, has been selected as the recipient of a $500,000 grant from the 2023 Mars Shot Fund the Society of Nuclear Medicine and Molecular Imaging, or SNMMI, announced June 7. The grant recognizes individuals who have made transformative impact in the field and elevated the value of nuclear medicine and molecular imaging.

The grant is one of five awarded in the inaugural year of the new SNMMI Mars Shot Research Fund, which was established to provide resources that translate visionary nuclear medicine imaging, radiopharmaceutical therapy and data science research or projects into tools or treatments that will help improve the lives of patients.

Sutcliffe’s Mars Shot grant was awarded based on her proposal, “Evaluating the integrin αᵥβ₆-targeted molecular imaging agent [⁶⁸Ga]Ga DOTA-5G as a diagnostic for lobular breast cancer.”

Invasive lobular breast carcinoma, or LBC, is the second most common type of breast cancer and is often difficult to detect noninvasively by imaging such as mammography and ¹⁸F-FDG-PET, warranting the need for better molecularly targeted PET imaging agents for detection and monitoring.

“We have identified the integrin αᵥβ₆ as a promising molecular target,” Sutcliffe said. “We designed a peptide, called DOTA-5G, that targets the integrin αᵥβ₆ on tumor cells. We then further developed DOTA-5G into a theranostic pair, [⁶⁸Ga]Ga DOTA-5G/[¹⁷⁷Lu]Lu DOTA-ABM-5G, which is currently being tested in patients with metastatic pancreatic cancer. We are now proposing to use [⁶⁸Ga]Ga DOTA-5G in patients with invasive LBC. We hypothesize that the agent will detect lesions, will be safe and well tolerated, and will be more sensitive than ¹⁸F-FDG PET.”

“This study will enable patients to receive more effective imaging that will improve their care by detecting disease earlier,” she added. “We therefore expect this molecularly targeted approach to have an immediate and much-needed benefit for this subpopulation of patients.”

Sutcliffe is a professor of biomedical engineering and internal medicine, co-director of the UC Davis Center for Molecular and Genomic Imaging and director of the Radiochemistry Facility. Sutcliffe’s research spans basic science, preclinical development and clinical translation with the ultimate goal of detecting and treating cancer earlier. She received her bachelor’s degree in chemistry from the University of Leicester, her master’s in synthetic organic chemistry from the University of London, and her doctorate in medicinal chemistry from King’s College London in England. Sutcliffe is a Fellow of SNMMI and also of the World Molecular Imaging Society and the American Institute for Medical and Biological Engineering.